Friday, November 29, 2019

15 Meta Description Examples, Plus How to Write a Perfect Description

If youre confused about how to write your meta descriptions, youre not the only one. To help remove that confusion, Im going to dig into what makes a great meta description and share 15 killer meta description examples.Youll also learn why your sites meta descriptions are so important, as well as the best length for your meta descriptions (especially taking into account Googles changing policies). Why is your contents meta description important?Back in September 2009, Google announced that the text in meta descriptions and meta keywords doesnt factor into its ranking algorithms for search.But meta descriptions are still important for two reasons:They help convince people to click on your result in the organic listings.Because Google measures CTR rate, they might indirectly improve your rankings by boosting your sites organic CTR.How long should your meta description be?When Google increased the length of search descriptions to 320 characters back in December 2017, SEOs got a little t oo excited and started re-writing meta descriptions for their sites. So it’s no surprise many started freaking out in May 2018 when Google unexpectedly dropped the length back to 160 characters.The fact is, Google has never explicitly stated how long meta descriptions should be, even when they’ve made sweeping changes to search pages. In fact, Googles public liaison of search, Danny Sullivan, advised against rewriting descriptions.Yes. Its not your imagination. Our snippets on Google have gotten slightly longer. And agree with @rustybrick dont go expanding your meta description tags. Its more a dynamic process. https://t.co/O1UTyFeNfA Danny Sullivan (@dannysullivan) December 1, 2017As Google Webmaster Trends Analyst John Mueller pointed out on Twitter, search is in a constant state of flux – and SEOs are along for the ride:The search results UI is a very dynamic place, seeing changes there is not unexpected. Like on your own sites, its also important to us to keep testing, improving, trying out new things to see what works best for users on our pages. John ☆.o(≠§Ã¢â€" ½Ã¢â€° ¦)o.☆ (@JohnMu) May 14, 2018Mays drop back to 160 characters prompted a flood of frustration on Twitter from people who just want clear guidelines from Google around how long to write meta descriptions. But as Sullivan pointed out, the search giant doesn’t want people to focus on character count – they want site owners to focus on delivering what works for visitors.Giving numbers makes people focus on numbers, not content. Thats not helpful. We provided some careful and thoughtful advice about all this, when we were asked in December. Id encourage you and others to read it. https://t.co/l6VPzUvA6c pic.twitter.com/1bIPLLyqtQ Danny Sullivan (@dannysullivan) May 14, 2018In other words, Google wants authentic, quality content in search. You don’t need to read between the lines to understand that Google wants people to focus on improv ing the quality of their content instead of tweaking meta description examples to lure visitors to their sites.Heads up: Google doesn’t always use meta descriptionsIt’s important to know that Google won’t always display your descriptions as intended. In fact, according to a Moz analysis, only 35.9% of original meta description tags are displayed â€Å"as is† in Google search.The Moz study, which examined 70,059 original meta description examples, also discovered that:In 15.4% of cases, Google used the original meta description tag but added some text.In 51.3% of cases, the display snippet perfectly matched the meta description tag or fully contained it.In 3.2% of cases, the display snippet used a truncated version of the meta description tag with an ellipsis on the end.In total, Google used all or part of the original meta description in 55% of cases.So what’s going on here? Basically, Google may choose to overrule the meta descriptions in the HTML of your web pages if they don’t adequately answer a user’s query, instead, using a snippet from your page that provides a better match for the query.Or†¦ Google might just use your existing meta description. It really depends on what the user has entered in search.Go to topHow to write a great meta descriptionTo write 160 characters or not to write 160 characters? That is the question.My advice? Use 160 characters for your meta descriptions, but don’t obsess over it, i.e. if your description is 161 characters, don’t waste time trimming it. Instead, focus on these tips:Stick to your brand voice and tone, but also keep it conversational.Include your primary keyword if you can do so naturally.Make sure you convey value to the reader.Include a call-to-action, i.e. â€Å"Learn more here.†Write in active voice.Make sure your descriptions match your content – don’t trick the user into clicking your link.Keep in mind that meta descripti ons might be truncated when displayed in search, so use the first 120 character to communicate your most important message.Ensure every page on your site has a unique meta description – don’t use the same description on several pages.Once you have your description figured out, you can set it in WordPress by following this guide.Go to top15 great meta description examples to inspire youSince you only have 160 characters to work with, writing a great meta description takes more than just throwing a few words together. To help you get your creative juices flowing, here are some meta description examples for your inspiration.1. TeslaWhy it works: In just 22 words, Tesla’s description conveys what the company represents, what it produces, its brand values, and ambitions. Now, that’s great copywriting.2. Lonely PlanetWhy it works: Well, do you love travel? Starting with a question draws readers in, making the description personal. It goes on to explain exactly how Lonely Planet helps travelers, all within the 160 character count.3. redditWhy it works: reddit not only includes its company mantra – the best of the internet – in its description, but also provides a clear explanation of what it provides, along with the word â€Å"you† at the end for an added personal touch.4. WiredWhy it works: For this article meta description, Wired teases readers, describing reddit as a former â€Å"dystopian Craigslist,† before going on to say it has grown up. Intrigued? Try not to click through, I dare you.5. Travel YosemiteWhy it works: Brief and straight to the point, this meta description clearly explains the value of the Travel Yosemite site and what visitors can expect when they click the link.6. GQWhy it works: While the meta title is cut, this meta description examples perfectly fits the recommended character count, teasing visitors with a fun fact from the article.7. LinkedInWhy it works: This meta description is Linke dIn’s standard paragraph for all LinkedIn business pages, simply swapping out the company name. The first sentence clearly explains the page’s value while the rest of the description provides a call-to-action for LinkedIn.8. The VergeWhy it works: Explaining a complex new story can be tough when you only have 160 characters to work with. But The Verge nails it with this succinct and descriptive tag.9. TypenestWhy it works: Okay, disclaimer – I wrote this meta description for one of my clients. I’m going to toot my own horn and say this description is friendly – perfectly matching Typenest’s brand values – but also compelling. I mean, who wouldn’t want to click through to find out more?10. SempliceWhy it works: Straightforward, descriptive, and no-nonsense, Semplice’s meta description tells you exactly what you’ll get when you click through.11. Bendigo BankWhy it works: Bendigo Bank embraces its brand identify, rea ffirming its ethos and values while also telling visitors why they’re different from other banks.12. Frito-LayWhy it works: It’s hard not to crack a smile when you read Frito-Lay’s description. It’s short, sweet, and creative, telling visitors they’re in for something fun if they click through.13. Taco BellWhy it works: Emotion sells, and Taco Bell nails all the feels in its meta description. Plus, it includes a simple call-to-action, using visitors to click through for offers and even order food now.14. UberWhy it works: For a company that is basically a taxi service, Uber manages to slip in some aspirational words, explain what it offers to drivers, and what it offers to riders, all in 160 characters.15. Hunting for GeorgeWhy it works: With the end of the financial year fast approaching in Australia, Hunting for George has done the smart thing and updated its meta description accordingly. The emojis as a nice touch and are eye-catching in search results.ConclusionMeta descriptions might not directly contribute to how Google ranks your web pages, but they certainly do help entice people to click your links. So nailing your meta descriptions should still be a priority when optimizing the SEO for your site. And when you can, try and stick to the 160 character limit.But that’s not to say you should be spending all your time optimizing meta description. What Google really wants is for you to spend more time coming up with clever, quality content. So as long as your content is useful for users and contains information that matches search queries, your pages will rank well in search.Have a question about how to write great meta descriptions? Know any other great meta description examples? Leave a comment below! Learn how to write the perfect meta description for your #WordPress #website - with 15 real examples

Monday, November 25, 2019

How to Speak Like a Italian Like

How to Speak Like a Italian Like If you want to learn Italian, forget your native tongue. If you want to speak Italian like a native, then spend some time in Italy speaking only Italian. If you want to read Italian, then pick up an Italian newspaper and peruse whatever section interests you. The point is, if you want to achieve competency in Italian, you must think like an Italian- and that means getting rid of the helpers that are real hindrances and standing on your own two (linguistic) feet. Bilingual Dictionaries Are a Crutch Speaking English to your friends is a waste of time if your goal is to speak Italian. Making grammatical comparisons between English and Italian are worthless. It sounds counterintuitive, but in the end, each language has rules and forms that are unique and sometimes illogical. And translating back and forth in your head before speaking or reading is the ultimate fools errand that will never lead to real-time speaking competence. Interact With Native Speakers So many people approach language as a science and get completely tongue-tied- witness the e-mail questions this SiteGuide receives daily about obscure Italian grammatical points and textbook recommendations. Learners obsess over minutiae, as if Italian could be dissected, instead of speaking Italian and interacting with native speakers. Imitate them. Mimic them. Ape them. Copy them. Let go of your ego and make believe youre an actor trying to sound Italian. But please- no books with something else to memorize. That turns off students immediately and is not effective in the least. Ignore English Grammar If there’s one bit of advice I can offer to anyone studying Italian, regardless of your level: Stop thinking in English! Ignore English grammar- you’re wasting a lot of mental energy trying to translate literally and construct sentences according to English syntax. In a letter to the editor in The New York Times Magazine, Lance Strate, an associate professor of Communication and Media Studies at Fordham University in The Bronx reinforces this point: ...it does not follow that all languages are equal, and therefore interchangeable. If this were true, the translation would be a relatively simple and straightforward affair, and learning another language would involve nothing more than learning to substitute one code for another, much like using Roman numerals. The truth is that different languages differ in highly significant ways, in grammar as well as vocabulary, which is why each language represents a unique way of codifying, expressing, and understanding the world. We do not become fluent in a new language until we stop translating and simply start thinking in the new language, because each language represents a distinctive medium of thought. Let Go of Your Fear of Making Mistakes Your goal should be to communicate, not sound as if you have a Ph.D. in Italian grammar (you’ll never do it, anyway, since there are only a small number of native Italians who are that well-versed in the intricacies of their own language. But certainly, most of them can communicate their every emotion, fear, want, and need.). Your biggest mistake, and what will hold you back, is using English as a crutch and being afraid of opening your mouth wide and singing that lovely language called la bella lingua. At the risk of sounding discouraging, a lot of language learners just don’t get it, and never will. It’s similar to taking dance lessons. You can put cut-out feet on the floor with numbers on them and take lessons from an expert, but if you don’t have rhythm, and you don’t have that swing, you’re always and forever going to look like a klutz on the dance floor, no matter how many lessons you take and how much you practice. So what do you do if you’re not a good dancer and weren’t born with natural rhythm? Scripted Responses Learning scripted responses in foreign languages is unproductive. Every textbook for beginners devotes many pages to dialogue that’s stilted and simply doesn’t occur in real life. So why teach it?! If you ask a person on the street Dov’e’ il museo? and he doesn’t respond according to the script you memorized, then what? You’re stuck, because there is an infinite number of potential responses, and none of us has enough time on the face of this earth to memorize them. And that person on the street is going to keep on walking because he’s headed to a great pizzeria. Learning scripted responses in foreign languages encourages a false sense of confidence. It doesnt translate into real-time speaking competence nor will you understand the musicality of the language. It’s like looking at a musical score and expecting to be a master violinist just because youve memorized the notes. Instead, you have to play it, and play it again and again. Likewise with the Italian language. Play with it! Practice! Listen to native Italian speakers and mimic them. Laugh at yourself trying to pronounce gli correctly. Italian, more so than many languages, is musical, and if you remember that analogy it will come easier. There is no secret, no Rosetta Stone, no silver bullet when it comes to learning a language. You have to listen and repeat ad nauseum. You will make a quantum leap in learning Italian when you abandon your native tongue and disengage from the grammar that you implicitly learned when you were a child.

Thursday, November 21, 2019

Excercise 3.1 Assignment Example | Topics and Well Written Essays - 250 words

Excercise 3.1 - Assignment Example The red color also implies stop and danger therefore stamping the perfumes title of the heat. Perfumes glass placed at the bottom right is bristle and clear. It also has a firm base showing stability and irresistibility of women who use the perfume (Beyonce Heat 1). Viktor & Rolf spicebomb is an attractive ad design. The image of a handsome young man holding the bottle implies the fragrance cozy, warm and composed nature. The masculine male shows that the product is designed for the gentle and handsome males in the society. Spicebomb’s bottle has a grenade shape thus qualifying the products name of ‘bomb’. In addition, spicebombs grenade and explosive nature implies the perfumes strength. Specifically, it signifies silage and the everlasting power of the fragrance thus sets it apart. The backgrounds grey shading creates a sense of calmness and confidence that the product creates. Black and white texts used in the ad improves the viewers or audiences public image. It also shows classism and perfumes distinct mainstream image. The title provides a seamless balance between intensity, elegance and subtlety (Rolf

Wednesday, November 20, 2019

The Kidnapping of the Lindbergh Baby Essay Example | Topics and Well Written Essays - 1000 words

The Kidnapping of the Lindbergh Baby - Essay Example It led to the arrest of Bruno Richard Hauptmann who was charged and convicted of murder in the famous case. He was sentenced to death and was executed at 8:44 p.m. on April 3, 1936 ("The Kidnappimg"). The trial had ended, but the controversy continues today. While some critics claim that Hauptmann was framed to save face for the government, others are convinced that Hauptmann was the perpetrator. A close look at the methods of the time, the exhaustive investigation, and the evidence surrounding the case leaves little doubt that 'Bruno' Hauptmann was instrumental in the crime. The case was controversial from the very first moments after the disappearance was discovered. It involved the son of the famous aviator, a beloved national hero. Immediately after the nurse, Betty Gow, discovered the open window and missing child, Lindbergh got a gun and went outside the house. He discovered a ladder near the open window and went to investigate. He trampled the footprints that remained and destroyed crucial evidence. In the flurry of confusion, the crime scene was contaminated. Local, state, and national law enforcement agencies all vowed to commit whatever resources were necessary to the investigation. However, the first errors in the case came when Charles Lindbergh insisted on being placed in charge of the investigation. Though the best professionals available had been assigned to the case, Lindbergh "[...] personally took charge, often ignoring the advice and overriding the decisions of the professionals" (Levy 34). These initial mistakes by Lindbergh would lea ve the case open to future criticism. A poorly written ransom note was found at the scene, though authorities were unable to find any fingerprints on it. The remains of the ladder, broken during use, were the only physical evidence. Lindbergh approved a plan to attempt to contact the kidnappers and arrange for the ransom to be paid after a second note was received on March 6, 1932 demanding $70,000. ("Famous Cases"). Within 10 days, a man named Dr. John F. Condon, Bronx, New York City, a retired school principal, contacted the Lindbergh's attorney and said he could mediate the safe return of the child. A series of meetings took place in a graveyard where Condon, code named 'Jasfie', and an elusive figure known as 'Graveyard John' discussed ransom and the child's safety. During one of these meetings, 'Graveyard John' offered proof of the child. According to the FBI, "A baby's sleeping suit, as a token of identity, and a seventh ransom note were received by Dr. Condon on March 16. The suit was delivered to Colonel Lindbergh and later identified" ("Famous Cases"). Arrangements were made to pay the ransom and secure the release of young Charlie. On April 2, ransom money was delivered to Graveyard John while Charles Lindbergh waited close by in an automobile. Graveyard John gave Condon a note which had instructions on the location of the child. The note said that the child could be found in Martha's Vineyard in a boat named Nellie, "between Horseneck beach and Gay Head near Elizabeth Island" ("The Kidnapping"). However, Lindbergh had been double-crossed as no boat could be located with that name and no baby was found ("The Kidnapping"

Monday, November 18, 2019

Law Essay Example | Topics and Well Written Essays - 1750 words - 2

Law - Essay Example The development of each of these areas of law would be discussed in turn and any similarity as well as difference would looked into so as to make an effective comparison between the two difference applications that have been provided for that is one by way of statute and the other would be that of the rule of Wheeldon v. Burrows and the cases that have effectively developed the rule and applied the provision. Easements are where a benefit is provided to the dominant tenement that is the land which benefits from the easement, which provides the person who owns the dominant tenement of land to use the easement. The second element in respect of an easement is the based on the fact that since there is a benefit that is accruing there is a burden on what is known as the servient tenement or in other words the land that has been burdened by the easement. A vital principle related to an easement is the fact that it is a proprietary interest and the accruing benefit and burden, subject to th e laws of registered and unregistered land, transfer, if the land that is either the servient or dominant tenement is transferred to another person. (Cursley et al 2009) The creation of an easement is dependent upon the satisfaction of a criterion that had been laid down in Re Ellenborough Park1 which are generally referred to when determining the existence of an easement. The first and foremost requirement is the fact that there must be a dominant and servient tenement thus eliminating the possibility and stating that the easement cannot exist in gross. (Hawkins v. Rutler)2. The second requirement is the fact that the dominant and servient tenement’s occupation and ownership must be by different persons (Roe v. Siddons)3. However, according to Wright v. Macadam4 the occupation by different persons would allow an easement to be created. The Third element is the fact the easement must benefit the dominant tenement and this is dependent upon the proximity of the servient teneme nt; it also been stated that the advantage should not be purely personal (Hill v Tupper); and the right must not that be of a recreational user. The fourth criterion is that the easement that has been alleged must be capable of formation of subject matter of a grant. Case law has developed upon the criterion and has provided guidelines in this respect, the first one being that there must be a capable grantor, which is clear in the facts at hand, the second that there must be a grantee which is evident because the tenants were granted the rights; thirdly the subject matter of grant is sufficiently certain, which is clear enough in respect of the facts that is the right to cross; and finally the right must be capable of being called an easement that is it is covered under the rights which have been recognized to be easements, which has been done in respect of the right to cross. The final factor that has not been expressly listed down in the case was that of public policy which is con sidered when determining whether an easement is existent or not. (Grey et al 2006) The next aspect that is considered is that easement can be existent either legally or under equity as laid down under section 1 of the Law of Property Act (LPA) 1925. (Cooke 2006) As far as legal easements are considered there are a number of formalities that need to be fulfilled. The first requirement is that for a legal easement there must either be a fee simple absolute in possession or as an adjunct to a term of years (section 1 Law of Property Act 1925). Secondly easements can only be legal if created by way of statute, by prescription, by deed or registered disposition. All other easement are equitable in nature. (Dixon 2004) As far easement by prescription is Law Essay Example | Topics and Well Written Essays - 1500 words Law - Essay Example Unfortunately, even in 2012, until more research is conducted to collect data on duration of street bail, Hucklesby’s claims remain valid. Street bail was introduced in the British legal system in 2003. The amendment came into effect in 2004.1 Street bail was designed to speed up justice in the British legal system by enabling officers to spend more time collecting evidence, and less on bringing the suspect in the police station to bail him or her out a few minutes later.2 There were estimates in 2004 that the new bail system would be economical, as it would provide additional 390,000 hours of police officers’ time annually to focus on investigating the crimes.3 Guidance on Street Bail was implemented in 2006. The guide aimed to direct implementation of the Sections 30A to 30D of the Police and Criminal Evidence Act 1984 (PACE), as amended by Section 4 of the Criminal Justice Act 2003. 4 While making a decision whether to bring the offender in or not, the police officer must consider following facts: whether the offender has a history of violating the bail, whether the offender could jeopardize the evidence crucial to the judicial system if left free, whether the offender could continue offending if left free, and whether data are correct regarding the address of the offender and the nature of the offense. 5 In Northern Ireland, an equivalent document was published as well.6 However, Hucklesby argues that the pre – charge bail system only discourages justice. The nature of the offense, or the ability to jeopardize evidence, is left to the interpretation of the police officer. As a result, Hucklesby argues, more arrests will take place, instead of fewer.7 Moreover, in cases where police officers will not be willing to pursue the investigation, the offender will not be turned in.8 Cape too agrees with Hucklesby’s arguments, due to the inexperience of the arresting officers and a low threshold for arrest and long bail periods, where sus pects will not be able to present their own story.9 Some argue otherwise. There are arguments that even in the light of the new approach to bail, PACE â€Å"continues to use its ‘fundamental balance’ approach,†10 which was abused in the past. PACE’s approach is to protect the rights of the suspect, while allowing for the police officers to gather enough evidence to identify the offender.11 One of its aims is also to decrease detention time. 12 A famous case portraying the misuse of power before the street bail on behalf of law enforcement officers is the Birmingham pub bombings, where six suspects were wrongfully convicted.13 The suspects were treated outside their protection system and tortured.14 Moreover, they were interrogated partly also outside of the police station, which violates the rules of PACE.15 The new approach to bail on street attempts to avoid such problems through allowing suspects freedom while conducting investigation. However, the powe r remains in hands of the arresting police officers. Though PACE aims to decrease the detention time, Skinns has found evidence that detention time has been increasing back to the pre – PACE level.16 In 1986, the mean detention time was over four hours, whereas in 1990 – 3 it increased to over six hours. 17 In 1979, before PACE, the mean detention time was over ten hours. 18 Moreover, police investigation is still a problem. Skinns found that gathering evidence is still a problem in the British criminal system, and it rests with â€Å"

Saturday, November 16, 2019

Plasmodium Falciparum Life Cycle

Plasmodium Falciparum Life Cycle Malaria is one of the world leading causes of death, especially among people living in sub-Sahara Africa and other tropical regions. Of the five species of the genus Plasmodium, the malaria protozoan parasite, known to infect Man, Plasmodium falciparum is responsible for the most virulent, severe and dangerous form of human malaria. Over the years, chemotherapy has played central role in the strategies towards the eradication of this disease. However, ability of P. falciparum to develop resistance to effective and affordable drugs and to pyrathroids, the active principle of the insecticides treated nets (ITNs) has made constant search for new pharmacotherapy imperative. This review presents an overview of the life cycle of the causative organism (P. falciparum), the efforts at controlling the disease and the molecular and cellular basis of the infection, with special emphasis on molecular chaperones of the heat shock proteins family as critical components of the parasite intra-erythr ocytic development and survival. The motivation for the present work is also presented. 1.1 Introduction Malaria, whose pathogen is transmitted by female Anopheles mosquitoes, is both preventable and curable, but yet still impacting negatively on the health of millions of people and account for high rate of mortality, especially among children in sub-Sahara Africa (Breman, 2001; Greenwood et al., 2008; Hay et al., 2004; Rowe et al., 2006; Snow et al., 2005). Five species of the genus Plasmodium, the protozoan parasites, responsible for malaria infection are known to infect humans. They are P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. It has been proposed that P. ovale consist of two species (Cox-Singh, 2010) and that zoonosis is the medium through which P. knowlesi infect humans (White, 2008). Of these, P. falciparum and P. vivax are numerically most important, with the former responsible for the most virulent, severe and dangerous form of human malaria (Greenwood et al., 2008). The World Health Organization (WHO) 2011 Malaria reports (WHO | World Malaria Report 2011, 2012) estimated a total of 216 million episodes of malaria in 2010 with at least 655 000 deaths, mostly in Africa and among children under the age of 5 years. Malaria was reported to be prevalent in 99 countries with an estimated 3.3 billion people at risk. Though, supports by international donors has led to rapid decrease in malaria mortality, especially among adults in Africa, Murray et al., (2012) contended that the malaria mortality burden may actually be larger than previously estimated and that for the necessary elimination and eradication to be achieved at larger scale, there is an urgent need for more supports. Factors, such as lack ofsanitation, malnutrition, lack or reduced access to medications, poverty and the location of many of the poor countries affected by malaria in the tropical zones, all combined together to create an enabling environment for the disease to thrive. Though pre ventive approaches such as good sanitation and distribution of insecticide treated nets (ITNs) (Curtis et al., 2006), have been employed as strategy towards the eradication of this disease, chemotherapy remains the most widely used approach. The ability of P. falciparum to develop resistance to effective and affordable drugs (Cheeseman et al., 2012; Jambou et al., 2005; Mller Hyde, 2010; Phyo et al., 2012) and to pyrethroids, the active principle of the insecticides treated nets (ITNs) (Fane et al., 2012; NGuessan et al., 2007) has made constant search for new pharmacotherapy imperative. Malaria parasite life cycle is a complex mechanism involving two hosts, human and female Anopheles mosquitoes. However, the clinical symptoms of the disease are associated with the invasion of the erythrocytes by the parasite, its growth, division inside the host cell and the cyclic cell lysis and reinvasion of new erythrocytes. The intra-erythrocytic survival and development of the parasite as well as the pathology of the infection are linked to structural and functional remodeling of the host cell through the export of parasite-encoded proteins (Botha et al., 2007; Miller et al., 2002; Pesce Blatch, 2009; Przyborski Lanzer, 2005). Meanwhile, attempts have been made to present an extensive description of the protein interaction network for P. falciparum (LaCount et al., 2005) and about 300 parasite-encoded proteins are predicted to be exported (Marti et al., 2004; Sargeant et al., 2006). Among the exported proteins are the molecular chaperones of the heat shock protein family (Nya lwidhe Lingelbach, 2006). Molecular chaperone are a family of proteins that function to stabilize proteins, facilitate their translocation across intracellular membranes, their degradation, and ensure that proteins in a cell are properly folded and functional (Hartl Hayer-Hartl, 2002; Hartl, 1996). PFA0660w belongs to an extended family of Hsp40 proteins predicted to be transported by the parasite into the host cell (Hiller et al., 2004; Marti et al., 2005; Sargeant et al., 2006). It is a Type II Hsp40 protein, said to be homologous to human DnaJB4, a cytosolic type II Hsp40, known to interact with human Hsp70 to facilitate protein folding, transport and assembly (Botha et al., 2007). Recent studies have localized PFA0660w into structures in the infected erythrocyte, called the J-dots (Kulzer et al., 2010); said to be exported in complex with P. falciparum Hsp70-x (PfHsp70-x) into the J dots (Kulzer et al., 2012) and failure to obtain a viable PFA0660w-knocked-out parasite (Maier et al., 2008), suggests that it may be essential for the survival of the parasite in the infected erythrocytes and therefore a potential target for drug action. 1.2 Malaria Infection 1.2.1 Background information Malaria, though curable and preventable, remains a life-threatening disease that was noted in more than 4,000 years ago and has being responsible for millions of death. World Health Organization (WHO) listed malaria among the most important infectious diseases of the tropics and form part of the sixth millennium development goal (MDG 6) (WHO | MDG 6: combat HIV/AIDS, malaria and other diseases, 2012). The target 6C of MDG 6 is to bring malaria and other major diseases to a halt by 2015 and begin to reverse their incidences. Strategies advocated by WHO to combat malaria includes prevention with the use of long-lasting insecticides treated bed-nets (ITNs) and indoor residual spraying, and rapid treatment with effective anti-malarial medicines with special focus on pregnant women and young children. WHO Roll Back Malaria further recommends that to control Plasmodium falciparum malaria during pregnancy, in addition to individual protection with ITNs and prompt management of anaemia and m alaria using effective anti-malaria drugs, intermittent preventive treatment (IPTp) or chemoprophylaxis should be encouraged (WHO | Malaria in pregnancy, 2012). Though, the World Health Organization (WHO) 2011 Malaria reports (WHO | World Malaria Report 2011, 2012) estimated at least 655 000 deaths as a result of malaria infection, mostly in Africa and among children under the age of 5 years, the mortality burden may actually be larger than previously estimated, thus, the need for improved supports by the funding organization to be able to achieve the much needed malaria elimination and eradication (Murray et al., 2012). Malaria is caused by the transmission of parasites to humans by female Anopheles mosquitoes during a blood meal. Plasmodium falciparum is known to be responsible for high rate of mortality, especially among children in sub-Saharan Africa, mostly under age 5 years (Breman, 2001; Greenwood et al., 2008; Hay et al., 2004; Rowe et al., 2006; Snow et al., 2005). Apart from the fact that many of the countries that are mostly affected are located in the tropical region of the world, increasing level of poverty, with its attendant economic consequences, coupled with lack of or improper sanitation and reduced access to prompt medication are factors that are creating enabling environment for the disease to thrive. Though preventive approaches such as the use of insecticide treated bed nets, IPTp and chemoprophylaxis with good sanitation (Curtis et al., 2006; WHO | Malaria in pregnancy, 2012), have been employed as strategy towards the eradication of this disease, the use of chemotherapeutic drugs remains the most widely used approach (Butler et al., 2010; DAlessandro, 2009). However, the success of this strategy has been hampered by the resilient of the parasite in continually creating resistance to the available drugs. The ability of P. falciparum to develop resistance to effective and affordable drugs (Cheeseman et al., 2012; Jambou et al., 2005; Mller Hyde, 2010; Phyo et al., 2012) and to pyrethroids, the active principle of the insecticides treated nets (ITNs) (Fane et al., 2012; NGuessan et al., 2007), has made constant search for new pharmacotherapy imperative. However, notwithstanding the centrality of chemoprophylaxis and chemotherapy in efforts at combating the menace of malaria infe ction (DAlessandro, 2009), and wide distribution of insecticide-impregnated bed nets, efforts aimed at enhancing long lasting protective immunity through vaccination, of which RTS,S is emerging as most promising vaccine formulation, have also been intensified (Ballou, 2009; Casares et al., 2010). 1.2.2 Life Cycle of Plasmodium falciparum Malaria parasite life cycle (Figure 1.1) is a complex mechanism involving two hosts, human and female Anopheles mosquitoes. The survival of the parasite during several stages of its development depends on its ability to invade and grow within multiple cell types and to evade host immune responses by using their specialized proteins (Florens et al., 2002; Greenwood et al., 2008). Sporozoites (infective stage), merozoites (erythrocytes invading stage), trophozoites (multiplying form in erythrocytes), and gametocytes (sexual stages) are stages involved in the development of the parasite. These stages are unique in shapes, structures and complementary proteins. The continuous changes in surface proteins and metabolic pathways during these stages help the parasites to survive the host immune response and create challenges for drugs and vaccines development (Florens et al., 2002). The sporogony or sexual phase occurs in mosquitoes, resulting in the development of numerous infective forms of the parasites which when ingested by human host induced disease. During a blood meal by female Anopheles mosquitoes from an individual infected with malaria, the male and female gametocytes of the parasite enter into the gut of the mosquito, adjust itself to the insect host environment and initiate the sporogonic cycle. The fusion of male and female gametes produced zygotes, which subsequently develop into actively moving ookinetes that pierced into the mosquito midgut wall to develop into oocysts. Each oocyst divides to produce numerous active haploid forms called sporozoites which are subsequently released into the mosquitos body cavity following the burst of the oocyst. The released sporozoites travel to and invade the mosquito salivary glands, from where they get injected into the human bloodstream during another blood meal, causing malaria infection (Barillas-Mury Kum ar, 2005; Ferguson Read, 2004; Hill, 2006). The parasite life cycle traverse two hosts (Man and Mosquito) with each stage involving complex cellular and molecular modifications. To prevent blood clots, Sporozoites infected saliva are deposited into Man during blood meal by female Anopheles mosquitoes, make their way to the liver, develop over time into hypnozoites (dormant stage, usually responsible for relapse of infection) or merozoites (that are released into blood stream to invade erythrocytes). The clinical symptoms of the disease are associated with the invasion of the erythrocytes by the parasite, its growth, division inside the host cell and the cyclic cell lysis and reinvasion of new erythrocytes. The schizogony or asexual phase of the life cycle occurs in human host. The cycle is initiated from the liver by the ingested sporozoites and later continues within the red blood cells, resulting in the clinical manifestations of the malaria disease. Following the introduction of invasive sporozoites into the skin after mosquito bite, they are either destroyed by macrophages, enter the lymphatics and drain into the lymph nodes from where they can develop into exoerythrocytic stages (Vaughan et al., 2008) and prime the T cells as a way of mounting protective immune response (Good Doolan, 2007) and/or blood vessel (Silvie et al., 2008b; Vaughan et al., 2008; Yamauchi et al., 2007), from where they made their way into the liver. While in the liver, sporozoites negotiate through the liver sinusoids, entered into hepatocytes, followed by multiplication and growth in parasitophorous vacuoles into schizonts, each of which contains thousands of merozoites, especially with P. falciparum (Ami no et al., 2006; Jones Good, 2006; Kebaier et al., 2009). Thrombospondin-related anonymous protein (TRAP) family and an actinmyosin motor has been show to help sporozoites in its continuous sequence of stick-and-slip motility (Baum et al., 2006; Mnter et al., 2009; Yamauchi et al., 2007) and that it growth and development within the liver cells is facilitated by the circumsporozoite protein of the parasite (Prudncio et al., 2006; Singh et al., 2007). This stick and slip motility prevent the parasite from been washed away by the circulating blood into kidney from where they can be destroyed and removed from the body. Motility is driven by an actin-myosin motor located underneath the plasma membrane. The sporozoite journey is propelled by a unique actin-myosin system, which allows extracellular migration, cell traversal and cell invasion (Kappe et al., 2004).This is a single cycle phase with no clinical symptoms, unlike the erythrocytic stage, which occurs repeatedly and characterize d with clinical manifestation. The hepatocytic merozoites are stored in vesicles called merosomes where they are protected from the phagocytotic action of Kupffer cells. The release of these merozoites into the blood stream via the lung capillaries initiates the blood stage of the infection (Silvie et al., 2008b). In some cases (as it can be found with P. vivax and P. ovale malaria) dormant sporozoites, called hypnozoites, are formed and remain in the liver for a long time. These hypnozoites are usually responsible for the development of relapse of clinical malaria infection and has been reported to be genotypically different from the infective sporozoites ingested after a mosquito bite (Cogswell, 1992; Collins, 2007). The development of the parasite within the red blood cells occur with precise cyclic accuracy with each repeated cycles producing hundreds of daughter cells that subsequently invades more red blood cells. The clinical symptoms of the disease are associated with the invasion of the erythrocytes by th e parasite, its growth, division inside the host cell and the cyclic cell lysis and reinvasion of new erythrocytes. The invasion of RBCs by the merozoites takes place within seconds and made possible by series of receptorligand interactions. The ability of the merozoites to quickly disappear from circulation into the RBCs protect its surface antigens from exposure to the host immune response (Cowman Crabb, 2006; Greenwood et al., 2008; Silvie et al., 2008b). Unlike P. Vivax, which invade the RBCs by binding to Duffy blood group, the more virulent P. falciparum possess varieties of Duffy binding-like (DBL) homologous proteins and the reticulocyte binding-like homologous proteins that allows it to recognize and bind effectively to different RBC receptors (Mayer et al., 2009; Weatherall et al., 2002). Micronemes, rhoptries, and dense granules are the specialized apical secretory organelles of the merozoite that help the merozoites to attach, invade, and establish itself in the red cel l. The successful formation of stable parasitehost cell junction is followed by entering into the cells through the erythrocyte bilayer. This entrance is made possible with the aid of the actinmyosin motor, proteins of the thrombospondin-related anonymous protein family (TRAP) and aldolase, leading to the creation of a parasitophorous vacuole, that isolate the intracellular ring parasite from the host-cell cytoplasm, thereby creating a conducive environment for its development (Bosch et al., 2007; Cowman Crabb, 2006; Haldar Mohandas, 2007). The intra-erythrocytic parasite is faced with the challenge of surviving in an environment devoid of standard biosynthetic pathways and intracellular organelles in the red cells. This challenge is overcome by the ability of the parasite to adjust its nutritional requirement to haemoglobin only, formation of a tubovesicular network, thereby expanding it surface area and by export of a range of remodeling and virulence factors into the red cell (Silvie et al., 2008b). Following the ingestion of the hemoglobin into the food vacuole, it is degraded to make available the amino acids for protein biosynthesis. Heme is a toxic free radical capable of destroying the parasite within the red blood cells. Heme polymerase is used by the parasite for the detoxification of heme and the resulting hemozoin is sequestrated as hemozoin. As the parasite grows and multiplies, new permeation pathways are created in the host cell membrane to help in the uptake of solutes from the extracellular medium, disp osal of metabolic wastes, and in initiating and sustaining electrochemical ion gradients, thereby preserving the osmotic stability of the infected red cells and thus, premature hemolysis (Kirk, 2001; Lew et al., 2003). 1.2.3 Control of Malaria infection Preventive measures are a critical step towards the control and eradication of malaria. Preventive approach can broadly be divided into two Infection control and Vector control. Infection control focuses on preventing the development of the disease as a result of occasional mosquito bite or relapse of previous infection (Lell et al., 2000; Walsh et al., 1999b). This involves the use of chemoprophylaxis. Travellers to malaria endemic countries are expected to start prophylaxis at least two weeks before and to continue up to two weeks after. One important target group in the infection control using chemoprophylaxis are the pregnant women. Intermittent preventive treatment for pregnant women (IPTp) is the globally acknowledge approach for prevention of malaria in pregnancy (Vallely et al., 2007; WHO | Malaria in pregnancy, 2012). Sulphadoxin-pyrimethamine (SP) has been used for this purpose and there are compelling arguments for the use of artesunate-SP (Jansen, 2011). To ensure long lasting prevention, this approach should be combined with vector control. Vector control focuses on protecting against mosquitoes bite, thereby preventing the transmission of the parasite to Man. Strategies for vector control include the use of residual spraying of insecticides, insect repellent cream or spray, sleeping under bed nets, especially, the insecticide impregnated bed nets (ITNs) and proper sanitation (Curtis et al., 2006; Lavialle-Defaix et al., 2011; WHO | Insecticide-treated materials,). WHO provides guideline for the production, preparation, distribution and the use of the ITNs (WHO | Insecticide-treated materials,). With the reported resistance to pyrathroids, an active principle of the insecticides treated bed nets (Fane et al., 2012; NGuessan et al., 2007), all strategies involving the use of chemical agents, also faces the global challenge of developing resistance. Training in proper sanitation and its sustainability from generation to generation is most probably the best approach in controlling the malaria disease. Personal and general hygiene which involve in-door and out-door cleaning, good refuse disposal practices, eradication of stagnant water, proper sewage disposal and clean, dry and uninterrupted drainages are examples of good sanitation practices that will not only prevent malaria infection, but also other killer diseases of the tropics. Sanitation is not only cheap and affordable; it is within the reach of everybody. 1.2.3.2 Malaria Chemotherapy Despite the use of preventive approaches outlined above (Curtis et al., 2006; WHO | Malaria in pregnancy, 2012), as strategy towards the eradication of this malaria, the use of chemotherapeutic drugs remains the most widely used approach (Butler et al., 2010; DAlessandro, 2009). They are widely employed as prophylaxis, suppressive and curative. However, the success of this strategy has been hampered by the resilient of the parasite in continually creating resistance to the available drugs. The ability of P. falciparum to develop resistance to effective and affordable drugs (Cheeseman et al., 2012; Jambou et al., 2005; Mller Hyde, 2010; Phyo et al., 2012) and to pyrethroids, the active principle of the insecticides treated nets (ITNs) (Fane et al., 2012; NGuessan et al., 2007), has made constant search for new pharmacotherapy imperative. Various approaches have been employed to identify new antimalaria agents with a view to reducing cost, ensuring availability and reducing the incidences of resistance (Rosenthal, 2003). Chemical modification of the existing antimalarial is a simple approach and required no extensive knowledge of the mechanism of drug action and the biology of the infection. Many drugs in use today have been produced using this approach, including chloroquine, primaquine and mefloquine from quinine (Stocks et al., 2001), 8-aminoquinoline, tafenoquine, from primaquine (Walsh et al., 1999a) and lumefantrine from halofantrine (van Vugt et al., 2000). Another approach is the use of plant derived compound with little or no chemical modification has led to the discovery of potent antimalarial such as artemisinins (Meshnick, 2001). Also, the use of other agents not originally designed for malaria such as folate antagonists, tetracyclines and antibiotics that were reported to be active against malaria parasit es (Clough Wilson, 2001) is another viable approach to drug discovery. Resistance reversals such verapamil, desipramine and trifluoperazine (van Schalkwyk et al., 2001) have also been used in combination with antimalaria drugs to improve therapy. Optimization of therapy with existing antimalaria agents is widely used as a productive approach towards improving therapy. Optimization of therapy underscore the need for combination therapy with newer and older drugs and with agents that are not original designed as antimalaria but which can potentiate the antimalaria property and/or block resistance to antimalaria agents. Thus for the combination to be ideal, it should improve antimalarial efficacy, providing additive or synergistic antiparasitic activity and slow the progression of parasite resistance to the antimalaria agents. For example, combination of artesunate with sulfadoxine/pyrimethamine (von Seidlein et al., 2000) or with amodiaquine (Adjuik et al., 2002), if devoid of underlying resistance to the artesunate partners which can lead to high rates recrudescence (Dorsey et al., 2002), may prove to be optimal antimalarial agents. Other combinations that have been effectively used include artesunate and mefloquine (Price et al., 1997) and artemether and lumefantrine (Lefevre et al., 2001). The combination of analog of proguanil (chlorproguanil) with dihydropteroate synthase (DHPS) inhibitor (dapsone), originally produced to treat leprosy (Mutabingwa et al., 2001) has open up a new and effective approach in antimalaria drug therapy. The use of dapsone and other drug resistance reversers such as verapamil, desipramine, trifluoperazine (van Schalkwyk et al., 2001) and Chlorpheniramine (Sowunmi et al., 1997) has shown potential for reducing the rate of drug resistance. Table 1.1: Classes and Mechanism of Antimalarial drugs CLASSES OF DRUGS Gametocidal Tafenoquine Gamatocidal Gametocidal biguanides (proguanil, cycloguanil), Trimethoprim CLASSES OF DRUGS Clindamycin, Spiramycin m ubiquinol to cytochrome C (Vaidya, 2001). Meanwhile, one important and innovative approach towards drug discovery in malaria chemotherapy is the search for new antimalaria drug target. Such targets include parasite membrane (Vial Calas, 2001), food vacuole (Banerjee et al., 2002), mitochondrial and apicoplast (Ralph et al., 2001; Vaidya, 2001). The cytosol, which is the centre of metabolic activities (e.g. folate metabolism and glycolysis) and enzymes activities have proven to be valuable as potential target for drug action (Plowe, 2001; Razakantoanina et al., 2000). To survive and develop within the erythrocytes, Plasmodium falciparum export most of its virulent factors into the cytosol of the infected erythrocytes. Among these are the molecular chaperones of the heat shock proteins which are focus of many researches and are increasingly gaining ground as potential target of drug action (Behr et al., 1992; Kumar et al., 1990). 1.2.3.3 Malaria Vaccines Notwithstanding the centrality of chemoprophylaxis and chemotherapy in efforts at combating the menace of malaria infection (DAlessandro, 2009), and wide distribution of insecticide-impregnated bed nets, efforts aimed at enhancing long lasting protective immunity through vaccination, of which RTS,S is emerging as most promising vaccine formulation, has been intensified (Ballou, 2009; Casares et al., 2010). These attempts at producing an effective vaccine against malaria infection has, however, for many years proved unsuccessful (Andr, 2003; Artavanis-Tsakonas et al., 2003). Having a vaccine that can completely block transmission from human to mosquito host can be a major limp towards global eradication of malaria. But, the absences of such immunity may explain the possible partnership between the parasite and the host, developed over a long time of co-habitation (Evans Wellems, 2002). On the other hand, a vaccine developed in line with the model of naturally acquired immunity that o ffers protections against morbidity and mortality, offers more encouragement. Such a vaccine will be a major step in the right direction and may not require regular booster vaccination like it would with vaccine that target infection transmission blockage (Struik Riley, 2004). Meanwhile, the development of natural immunity, after a long term exposure to the infection, especially with people living in the endemic areas has been reported (Baird, 1995; Hoffman et al., 1987; Rogier et al., 1996). The rate of acquired immunity in infants is faster than older children, but they also stand the chance of higher risk of developing severe malaria infection and anaemia (Aponte et al., 2007). Though, adults who, having obtained naturally acquired immunity, migrated to malaria-free zones, stands the risk of contacting the diseases upon return to their endemic region, documentary evidences however revealed that their responses to such re-infection are very rapid and tend to respond to treatment and recover faster than those who have not been previously xposed. (Di Perri G et al., 1994; Jelinek et al., 2002; Lepers et al., 1988). While this naturally acquired immunity is beneficial, it leaves the most vulnerable population (children and pregnant women though the mother may be immune, the foetus is not) at risk, as they are yet to gain enough exposure for such immunity to take place. Aponte et al., (2007) also showed that a reduced exposure toP. falciparumantigens through chemoprophylaxis early in life have the potential to delay immunity acquisition. Furthermore, it does not appear that naturally acquired immunity have any effect on transmission of malaria. This further explained the possibility of an evolving host-parasite relationship (Evans Wellems, 2002), which might have been developed over a long time host-parasite co-evolution. Therefore, understanding the compromises that may have developed over time between the parasite and the host may be an important approach towards developing a much needed vaccine. 1.3 Molecular and Cellular Basis of Malaria Infection Following blood meal by an Anopheles female mosquito accompany with the release of saliva to prevent blood coagulation (Beier, 1998), malaria parasites are deposited or ejection of into the skin (Frischknecht et al., 2004; Vanderberg Frevert, 2004). By continuous gliding in the skin, the sporozoite reach a blood vessel, breach the endothelial barrier and enter the blood circulation (Amino et al., 2007; Vanderberg Frevert, 2004) and/or breach a lymphatic vessel to enter the draining lymph node, where exoerythrocytic stages of sporozoites development may take place (Amino et al., 2006). A micronemal protein, called thrombospondin-related anonymous protein (TRAP), has been shown to be responsible for the gliding motility and invasion mosquito vector salivary gland and in mammalian host (Kappe et al., 1999). The sporozoite transversal to the liver and the merozoites invasion and remodeling of the host cells are complex but necessary processes for the survival and development of the par asite. 1.3.1 Cell Transversal Sporozoite possesses the ability to transverse cells i.e move in and out of the host cells by membrane disruption (Mota et al., 2002, 2001; Vanderberg Stewart, 1990). Among the proteins secreted by the micronemes that have been implicated in host cell traversal are SPECT1 (sporozoite microneme proteinessential forcelltraversal 1) and SPECT2 (Ishino et al., 2005, 2004). The absence of SPECT1orSPECT2in mutant sporozoite does not prevent gliding motility but prevent migration through host cells (Ishino et al., 2004).Other proteins of importance to sporozoite cell traversal prior to hepatocyte infection, includes TRAP-Like Protein (Moreira et al., 2008), a sporozoite secreted phospholipase (Bhanot et al., 2005), and celltraversal protein forookinete andsporozoite (Kariu et al., 2006). Similarly, the circumsporozoite protein (CSP) probably plays a role in targeting sporozoites to hepatocytes by interacting with heparin sulfate proteoglycans (Sinnis Sim, 1997). 1.3.2 Liver stage development Upon entering the bloodstream, infectious sporozoite makes it way to the liver. Circumsporozoite protein (CSP) is highly expressed at this stage of the parasite life cycle. Using the sporozoites that expresses fluorescent proteins under the control of CSP and intravital imaging, Frevert and colleagues were able to show the movement of sporozoites in the liver (Frevert et al., 2005). The study showed that sporozoite migrates through several hepatocytes before finally settling in one, form PV and begin the liver stage development. CSP, mediated by low-density lipoprotein receptor-related protein LRP-1, and other highly expressed proteins by Kupffer cells, play an important role in inhibiting the generation of reactive oxygen species via the generation of cyclic AMP (cAMP) which stimulates adenyl cyclase activity (Usynin et al., 2007). Ishino and co-workers reported that two parasite molecules P36 and P52/P36p are involved in sporozoite invasion of hepatocytes with the formation of a PV membrane (PVM) (Ishino et al., 2005). Apart from CSP, other gene product that has been implicated in liver stage development of the parasite includes sporozoite low complexity asparagine-rich protein (SAP1) (Aly et al., 2008) and sporozoite and liver stage asparagine-rich protein (SLARP) (Silvie et al., 2008a) 1.3.3 Erythrocyte Invasion Erythrocyte invasion involves four steps, namely, initial merozoites binding, reorientation and erythrocyte deformation, specific interaction and junction formation and parasite entry (Figure 1.2). Merozoite surface protein-1 (MSP-1) is a well characterized merozoite surface proteins implicated in initial merozoite binding. It has been reported to be uniformly distributed over the merozo

Wednesday, November 13, 2019

The Importance of Communication and Teamwork Among the Flight and Cabin

The Importance of Communication and Teamwork Among the Flight and Cabin Crew TABLE OF CONTENTS ABSTRACT 4 INTRODUCTION 5 Background 5 Purpose/Audience 5 Sources 5 Limitaions 5 Scope 5 COLLECTED DATA 5 Importance of Communication Among the Crew 5 Main Cause of Aircraft Accidents 6 Duties of the Crew Members 7 Expectations of the Crew 7 The Crew is a Team 8 Intimidatin in the Cockpit 8 Cabin Crew is a part of the Team 9 Trusting the Crew's Judgment 9 Crew Resource Management (CRM) 9 Outline of CRM Training 10 LOFT Training 10 Organizing Resources and Priorities 11 CONCLUSION 11 Summary of Findings 11 Interpretation of Findings 11 REFERENCES 13 ABSTRACT The majority of aircraft accidents are caused by human error, and an accident or incident is linked together by a chain of errors. Most of these accidents could have been avoided by the crew if they would have been communicating to each other better. Some common errors that occur among the crew are poor task delegation, assertiveness, and distractions. Crew training in communication and teamwork will increase the crews' performance level. Programs like Crew Resource Management (CRM) have been developed to try to help the crews work together and reduce the human factor in accidents. CRM includes training in leadership/followership, assertiveness, management, communication, teamwork, decision making, and task delegation. Through programs like CRM crews learn to work together as a team, and when they are working together it is less likely there'll be an accident. INTORDUCTION Background The cause for most aircraft accidents (65%) are by crew error (FAA News, 1996). When the Crews performance level is low due to poor teamwork and communication this is when accidents happen. How can crew error be reduced? Even though human error can't be reduced completely through constant training and effort by the crew performance will increase and accidents will be reduced. Purpose/Audience This report is intended for a general audience and will show how important it is for the flight and cabin crew to work together and communicate as a team. This report will also examine the CRM program. Sources Sources have been obtained for this report from the Internet and from the Waldo Library, Western Michigan University, Kalamazoo, Mich... ...grams like CRM are very helpful in instilling these principles and breaking the bad habits. Poor attitiudes and habits can't be changed overnight. That's why there is a need for recurrent CRM training. Communicaiton and teamwork is the key to safe and effective operations. There's no "I" in CREW but there is "WE". REFERENCES Chute, R. D. & Wiener, E. L. "Cockpit/cabin communication: I. A tale of two cultures." [http://olias.arc.nasa.gov/personnel/people/RebeccaChute/JA1.htm.]. Oct 1996. Federal Aviation Administration. (1995) Crew resource management training (AFS- 210, AC no. 120-51B). Washington, D. C. Nader, R. & Smith, W. J. (1994). Collision course: The truth about airline safety. PA: TAB Books. FAA News. "Atlantic coast airlines first to use FAA crew performance program." [http://www.dot.gov/affairs/apa15596.htm]. Sept 1996. Helmreich, R. L. "The evolution of crew resource management." [http://www.psy.utexas.edu/psy/helmreich/iata96/htm]. Oct 1996. Chute, R. D. & Wiener, E. L. (1996). Cockpit-cabin communicaiton: II. shall we tell the pilot? The International Journal of Aviaiton Phychology, 6 (3), 211- -229

Monday, November 11, 2019

Installation Art Essay

Out of the many ways in which we can view Installation Art, the term itself is not clearly defined. There are, however, different characteristics of it, and within this essay I will discuss the two most prevalent from my own point of view, and support my thoughts and opinions with examples from information we have encountered throughout this past semester. Although Installation Art has many qualities that it can be associated with, I believe that one which stands true above most is the fact that it Installation Art often casts the spectator as the protagonist. As we have seen throughout the semester, many different artist’s have employed their own ideas of what makes art Installation Art, yet from my own vantage point, it is only Installation Art if we create something for the spectator to walk into and ‘do’ something within the piece itself, as opposed to viewing it from a more museum like way, in order to create a more ‘authentic’ form of art. Lucas Samaras’s creation of ‘Room’, is a direct example of my thoughts on this characteristic of Installation Art. He wished to accommodate the viewer in his work. In this piece, he wished that the space of the piece become â€Å"a wholly immersive environment in which the space existed for the viewer to activate as an engaged and absorbed participant† (Bishop, 27). Installations should be geared toward first hand, real experiences by the viewer, and not illustrate simply a situation. Samaras’ ‘Room’ created this by having the items in the piece ‘fluid’, and not ‘glued-down’. ‘Room’, was a conglomeration of the artist’s own personal belongings reconstructed to mimic his own bedroom, in which the viewer could walk in, sit down on, and actually interact with the items, which, according to Samaras, created the ‘authentic’ quality of the art itself. As we view the characterstic of Installation Art as the spectator casted as the protagonist, we can now realize that, once again looking at Samaras’ ‘Room’, it addressed itself directly to the viewer, whose experience was not that of a detached onlooker, but was indeed the actual focus of the work itself. Samaras created a state of mind more than anything, in which the viewer was essentially in the first-person, and the subject actually will see things through their own ‘daydream’, which is nothing less than escape from a reality that is not completely suspended (in contrast to dreams while we are sleeping, in which we are suspended). According to Freud, a daydream is initially the expression of an unconscious fantasy, as a sort of ‘hallucinatory’ sense and is an escape from reality, which centers the viewer as the protagonist in the piece, because they are the one’s creating the art in which they see.

Friday, November 8, 2019

Why University Admission Essays Get Denied

Why University Admission Essays Get Denied Why University Admission Essays Get Denied Every year thousands of university admission essays are reviewed by Toronto university boards. The purpose of these essays is to narrow the list of applicants to the students that meet stringent university standards. While no two schools share the same set of admission and essay criteria, these factors should be taken into consideration: GPA Your qualities as a student (including extracurriculars and strengths) Your future contribution to the university, if accepted These key elements can direct your outline as you draft your essay. Here are some reasons admission essays get rejected: Grades don’t meet university requirements. Many universities are academically competitive. For some hopeful candidates, their grade point average may be the reason their essays aren’t even read. Incomplete application. One institution may requires three essays on different topics and another may asks for only one essay, in addition to quantitative data like test scores. Some applicants make the mistake of â€Å"copying and pasting† the same application for different institutions without reading individual requirements. Read each university’s instructions carefully. Wordy essay. Every admissions board reviews hundreds of applications. They are likely to quickly dismiss essays that are filled with incoherent ramblings. Write in a clear and direct tone and delete unnecessary â€Å"flourishes.† Vague writing. An essay that glosses over or omits important details can lead to rejection of a candidate. Writing that fails to cite specific examples (or an essay loaded with general pronouncements that have little meaning) will be discarded. Multiple errors. If your essay is rife with spelling and grammatical mistakes, it gives the impression you pay little attention to detail. Proofread your work and ask your guidance counsellor or a trusted teacher to review your essay and give honest feedback. Limited enrollment. Sometimes there simply aren’t enough spots for qualified candidates. In this case, acceptance or rejection may seem somewhat arbitrary, but a polished essay will increase your likelihood of admission. An admissions essay is a tool that helps universities narrow their list of potential students accepted for the upcoming term. This essay can encapsulate a student’s academic profile and/or indicate their future potential. Some applicants may struggle to write multiple essays, which can be both frustrating and discouraging. in Toronto employs professional writers who have experience writing quality college admissions essays. Our friendly team of writers are more than happy to help you draft a college admissions essay. To increase your chances of getting accepted into your dream school,

Wednesday, November 6, 2019

20 English Project Topics on the Relationship Between the Language and Culture

20 English Project Topics on the Relationship Between the Language and Culture Writing a project or an essay on the relationship between language and culture can be termed as one of the more difficult writing tasks out there due to the limited information on the subject matter. Therefore, to ease the troubles of anyone assigned with such a project, this article was written to provide you with a roadmap that can be followed right from the start to develop your own thoughts. But before delving into today’s topic, it is important for you to know that this is the second article in a 3 article series covering the relationship between language and culture. These three articles were written to provide you with facts, essay project topics and sample essays on how to go about working on your project. Now, the second article will help you choose topics on the relationship between language and culture for your essay. Lastly, included below is a sample essay chosen from the provided list and worked on to provide you with a realistic view of the task ahead. So sit back, relax and soak up the timely information contained here as it will serve you perfectly when working on any writing projects. Here are the topics: Discussing the Relationship Between Language and Culture Cultural Learning in Language Education The Relationship between Language and Culture and the Implications for Language Teaching How Does Culture Influence Language? The Role Culture Plays in Learning the Second Language The Role of Culture in Cross-Cultural Communication The Relationship Between Language, Culture and Gender The Relation Between Language, Culture and Thought The Role of Culture in Teaching and Learning Languages The Inseparable Link Between Language and Culture Language, the Individual, Society and Language How Culture Influences the Way We Speak Developing Cultural Awareness in Foreign Language Teaching The Importance of Teaching Culture in Foreign Language Classrooms Exploring the Relationship Between Language and Cultural Identity Symbols and Language in Human Culture Understanding the Factors that Influence the Acquisition of a Second Language The Effect of Environment and Culture on Language Development Is Language Acquisition a Cultural Process? How Culture Affects the Language Development Process of Children These are definitely some cool essay project topic on the relationship between language and culture for your project. Very important is the fact that most of these topics are quite easy to research and draft when the need arises. But if you are still at a loss on how to proceed, the next paragraphs will provide a sample article based on one of the topics on the list. The chosen essay topic is ‘The Role Culture Plays in Learning a Second Language’. As earlier stated, this essay is written with the aim of providing you with appropriate guidelines on how to easily draft an essay on any of the topics on the list above. Sample English Project: The Relationship Between a Language and Culture The National Centre for Cultural Competence defines the term culture as an integrated pattern of human behaviour that includes thoughts, communications, languages, practices, beliefs, values and customs as well as the expected behaviour of a racial, ethnic or social group and the ability to transmit the above to succeeding generations. This means that language is not just a part of how culture is defined but it also reflects culture. This means learning a second language is quite synonymous to understanding the culture that had born that language and this essay will attempt to shed more light on the roles understanding a society’s culture has to play in learning the language synonymous to it. Linguists and anthropologists have since stated that learners of a new or second language must acquire knowledge of the culture for this gives them insight into the use of certain terminologies and the intonations that go appropriately with them. This simplifies communication for the learner as it ensures that he or she uses the right expressions when greeting, making requests and concurring or disagreeing with someone. Such in-depth understanding eliminates the possibility of accidental misunderstandings or fracas occurring due to the student’s poor command of the language. It is also a known fact that language is the basis for communication. And communication is not just an exchange of information, but it is a highly cognitive and important activity that takes into context the social life and the lifestyle of a people. Therefore teaching cultural differences as well as what is acceptable by a culture to students learning a new language provides the learner with some perspective of how people from that particular culture view the world. For example, it is important that students understand how seriously position or seniority is viewed in France so they make use of the right pronouns when addressing people in authority when speaking in French. This cultural knowledge will provide students of the French language with the understanding needed to use the informal form of address ‘tu’ or the formal form ‘vous’ in an appropriate manner. The importance of culture has also been in highlighted by many foreign language teachers who believe that culture should be taught as a fifth language skill in addition to listening, speaking, reading and writing due to its role in understanding the expressions and terminologies of a language. These teachers also believe that when teaching a new language or culture to a set of students, the teaching process should be devoid of racism, superiority complex and any preconceptions or stereotyping. This is because such factors may affect the attitude of the learner towards the people from a particular culture thereby integrating a condescending attitude in the student’s speech patterns. In conclusion, learning a second language is one of the best ways to receive insight into the cultural way of life prevalent in a society. And this makes it important for students, to learn more about the culture that produced the second language they have considered learning. Here we come to the end of the second article in the Language and culture series and we believe this sample will provide you with the information you need to draft an excellent essay on today’s subject matter. References: Campbell, L. (1997). The Sapir-Whorf hypothesis. http://venus.va.com.au/suggestion/sapir.html Dhur, K. (2004). General Introduction to Sociology: A theoretical perspective. Goode, T., Sockalingam, S., Brown, M., Jones, W. (2004). Infusing principles, content and themes related to cultural and linguistic competence into meetings and conferences. georgetown.edu/research/gucdc/nccc/ncccplannersguide.html Maiga, C. (2004). Learning Culture and Language through ICTs: Methods for Enhanced Instruction 25-30. https://books.google.com.ng/books?id=ihwv7TNtUSgCpg=PA272lpg=PA272dq=+cal.org/resources/digest/0309peterson.htmlsource=blots=fa63R4Ck0xsig=wO9jD4nxFXN3Y50xaZhGExKz-hUhl=ensa=Xved=0ahUKEwi-vNC1x4TOAhVJBMAKHS_nBAYQ6AEILzAE#v=onepageq=http%3A%2F%2Fwww.%20cal.org%2Fresources%2Fdigest%2F0309peterson.htmlf=false Crystal, D. (2002). The English Language 38-45. Brock, N. Nagasaka, Y. (2005). Teaching pragmatics in the EFL classroom? SURE you can! TESL Reporter, 38 (1), 17-26. Jiang, W. (2000). The relationship between culture and language, 54(4), 328- 334.

Monday, November 4, 2019

The Chinese Zombie Essay Example | Topics and Well Written Essays - 500 words

The Chinese Zombie - Essay Example . Zombies are portrayed as â€Å"beings† operating in the universe that hardy understand or care to understand. In this speech, I focus on Chinese Zombie, also known as jiangshi, and how they influence Chinese cultural identity. The account is based on chapter eight, Gothic monster and Chinese cultural identity: analysis of the note of ghoul, from the book "Thinking Dead: What the Zombie Apocalypse Means." In the Chinese culture, the Chinese zombies are categorized as either male or female for particular reasons. In the Note of Ghouls, resurrected zombies have their gender as male. The female zombie that existed was later on adjusted to a ghost. A reason for this could be that it was only those bodies that had least deterioration that could be resurrected back as zombies. In most cases, it was only the bodies of tomb owners that were well preserved. Historical accounts of Chinese society indicate that it was of patriarchal nature, thus implying that tomb owners were male. Women ended up being buried alongside the owner just as mortuary bodies. It is thus presumed that the feeling of resentment for being sacrificed in favour of the tomb owner drove them to convert into lingering ghosts upon their deaths. Also, there exist accounts that assert that women bodies were used to cultivate the male zombies. Generally, female gender was not given much credit as to the male gender.

Saturday, November 2, 2019

TV Makes People Dumber Essay Example | Topics and Well Written Essays - 750 words

TV Makes People Dumber - Essay Example This essay generally believes that TV is bad for the youth. TV makes people dumber because it teaches racial prejudice and discrimination, it may boost memory, but not critical thinking skills, and it may be too complex for their cognitive and emotional levels, thereby limiting their ability to maximize potential learning from it. TV shows, even those with complex narratives, contains ideas that promote racial prejudice. Steven Johnson, in his essay, â€Å"Watching TV Makes You Smarter,† maintains that TV is good for people’s brains because many shows, including bad ones, have complex narratives with multiple-occurring plots. The complexity of TV stories compels people to think deeply, and this thinking makes them smarter. This paper opposes this argument because 24 may have a complex narrative, but it promotes racial stereotypes about Arabs and Muslims. It turns race into a literal black-and-white plot of morality, disabling people from realizing that TV is just a stor y, not a valid generalization of racial identities. Furthermore, some reality TV shows suggest that racial prejudice is fun and entertaining. Scholastic Scope explores the dangers of watching reality TV shows in â€Å"Is Reality TV Making You Stupid?† ... ho are negatively portrayed on TV and movies, such as what Dana Stevens highlights in â€Å"Thinking outside the Idiot Box.† Teenagers might think that racism is nothing serious and become discriminatory to minorities. Moreover, Reality TV might be making people stupid because it portrays negative values and conduct. It teaches selfishness. Most shows are about â€Å"me† than about â€Å"we.† In addition, reality TV teaches materialism. Shows such as My Super Sweet 16 underscore the negative effects of TV on the young mind. They might learn that materialism is good for their lives. Aside from potentially forming negative conduct, TV may improve memory, but not critical thinking skills. Susan Smith presents some evidence that TV is good for the brain in â€Å"TV Makes You Smart.† She mentions a study which provides findings that watching TV, especially comedy, can enhance memory. Johnson agrees with Smith and says that TV is a memory-booster because people have to memorize plots and characters to understand what they are watching. However, this essay argues that comedy and complex dramatic narratives might be good for the memory, but they are not true cognitive workouts as Johnson claims. It may produce short-term memory enhancement, but it does not train young minds to challenge what they watch. Moreover, watching TV makes people want to watch more TV only because it captures attention. Stevens believe that instead of making people smarter, TV merely conditions people to watch more. Watching more TV, if it does not make people smarter and can even make them dumber, will only make matters worse for people’s ability to think critically. In addition, watching TV trains people to be sensitive to changing actions and social relationships, but not how to question these